Background: Fine needle aspiration biopsy is usually performed to evaluate thyroid lesions. The purpose of this\r\nstudy was to evaluate the usefulness of diffusion weighted imaging to differentiate malignancy of thyroid lesions.\r\nMethods: The study was approved by ethics committee of Shanghai Changzheng Hospital.Forty-two patients,\r\n10 men and 32 women (range: 20ââ?¬â??72 years, mean age 42.4 years) with thyroid lesions were included in the study.\r\nRoutine neck MR and diffusion-weighted MR imaging was performed using multiple b-values. ADC values were\r\ncomputed for the different b-values. Histological results of the thyroidectomy samples were obtained for all the\r\npatients. ADC values of benign and malignant thyroid lesions were compared with the pathology results. Logistic\r\nregression analysis was used to detect independent parameters for differentiating benign and malignancy of lesions.\r\nResult: Based on the histology results there were 28 benign and 14 malignant cases. The difference of ADC value\r\nbetween benign and malignant thyroid lesions was significant for ADC values obtained using b-values of 0 and 300 s/\r\nmm2 (p < 0.001). The ADC values were significantly higher in benign lesions (benign ADC: 2.37 Ã?± 0.47 Ã?â?? 10-3 mm2/s vs.\r\nmalignant: 1.49 Ã?± 0.60 Ã?â?? 10-3 mm2/s). ADC values obtained with b-values of 0 and 300 mm2/s and max nodular diameter\r\nwas regarded as the two most discriminative parameters for differentiating malignancy. Using the pathology results as a\r\nstandard reference, area under ROC curve was found to be 0.876 for an ADC cutoff value of 2.17 Ã?â?? 10-3 mm2/s that\r\ncorresponded to an acquisition with b-values of 0 and 300 mm2/s.\r\nConclusion: Diffusion-weighted MR imaging is a promising non-invasive method to differentiate malignancy in thyroid\r\nlesions.
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